Do you always feel tired and exhausted? Constant fatigue has many causes, from food intolerances and vitamin B12 deficiency to metabolic disorders or too much caffeine consumption. In this article, CARE provides a guide to constant fatigue and tiredness. Together, we'll examine the potential causes and solutions to help you regain vitality.
Published in Sleep
9 min read · Apr 24, 2024
Feeling tired all the time can be a complex phenomenon caused by a variety of biological factors. Sleep, dietary habits, hormonal imbalances, your lifestyle, or certain illnesses can lead to a persistent feeling of tiredness and fatigue. [1] [2]
Biologically, fatigue can be caused by various processes in the body, particularly the interaction of neurotransmitters such as adenosine, which accumulates in the brain throughout the day and promotes drowsiness. In addition, your body reacts to your biological clock, the circadian rhythm, and external light influences, which together control the sleep-wake cycles. Basically, fatigue serves as a natural signal from the body that rest and recovery are needed — there can be many reasons why your body asks for rest. [3]
Your body may need rest to repair body cells, strengthen the immune system, or support cognitive functions such as memory and learning. Maybe you even have bloating and a disrupted gut flora that rob your body of energy. The reasons why you are fatigued can therefore be very diverse.
The physiological sign of tiredness aims to help you maintain your health and performance in the long term. If you are fatigued all the time, you should find out where the exhaustion and fatigue have their roots.
CARE has summarized possible causes of constant tiredness and fatigue:
For many people, sleep is central to constant fatigue. Quality, duration, and regularity of sleep are crucial for the recovery of the body and mind. Insufficient or disrupted sleep, such as sleep apnea, blue light from screens, or insomnia, can lead to chronic fatigue.
Not getting enough sleep can disrupt your internal clock – your sleep-wake cycle – and can lead to fatigue over an extended period of time. [4]
Hormonal imbalances also play an important role in fatigue. For example, hypothyroidism, which is associated with reduced levels of thyroid hormones, can lead to constant fatigue. Similarly, low testosterone levels in men and changes in estrogen and progesterone levels in women can cause fatigue. [5]
Another biological cause of constant fatigue is anemia, a lack of red blood cells that leads to insufficient oxygen supply to the organs. This can noticeably lower energy levels and cause persistent fatigue. [6]
Chronic inflammation and autoimmune diseases such as rheumatoid arthritis or lupus can also lead to constant fatigue as the body constantly fights against these inflammations. [2]
The diet also has a significant impact on your body's energy levels. An unbalanced diet comprised of processed foods (chicken nuggets, pizza, etc.) and low in essential nutrients (omega-3 fatty acids, vitamins, proteins) can lead to a lack of energy and, therefore, fatigue. [2]
Post-viral fatigue syndrome, also known as post-viral exhaustion syndrome, leads to persistent fatigue after a viral infection such as COVID-19. This condition is characterized by a persistent immune response that remains active even after the actual infection has subsided. [7]
In this state, your body uses a lot of energy for immune activity, which leads to persistent exhaustion and fatigue. In addition, inflammatory processes in the body can affect the nervous system and further increase tiredness.
An iron deficiency can also lead to fatigue, as iron plays an essential role in producing hemoglobin, a component of red blood cells responsible for transporting oxygen throughout your body. With a lack of iron, the body cannot produce enough hemoglobin, resulting in a reduced oxygen supply to organs and tissues. [2]
This insufficient oxygen supply means cells cannot work efficiently, leading to weakness and fatigue. Chronic iron deficiency can also affect muscle and brain function, further increasing feelings of fatigue.
A vitamin B12 deficiency can lead to fatigue, as this vitamin is crucial for the production of red blood cells that transport oxygen throughout the body. A lack of vitamin B12 can lead to a form of anemia known as pernicious anemia, which affects the oxygen supply to cells, causing fatigue and weakness. [2]
In addition, vitamin B12 is important for the function of the nervous system and efficient energy metabolism. A deficiency can, therefore, cause neurological symptoms and reduced energy production, further increasing the feeling of fatigue.
With a health check-up at CARE you can determine your vitamin B12 level and many other important biomarkers.
Caffeine, which is found in coffee, certain teas, and energy drinks, works by blocking the adenosine receptors in your brain. Adenosine is a neurotransmitter that builds up in your brain throughout the day (when you're awake). Adenosine triggers feelings of sleepiness and relaxation and naturally increases by the evening to make you tired and prepare your body and brain for sleep. However, caffeine blocks these adenosine receptors and prevents the adenosine from docking onto them and making you sleepy. Over the course of the day, more and more adenosine accumulates in your brain. Incidentally, while you sleep, your brain breaks down the adenosine again. [8]
However, with regular and high caffeine consumption, your body can no longer break down the adenosine accumulated throughout the day while you sleep, so you wake up tired.
A lack of regular physical activity can lead to decreased physical fitness and reduced cardiovascular efficiency. This, in turn, can affect blood flow and oxygen supply to the body and brain, leading to fatigue and a general lack of energy. In addition, lack of exercise can lead to poorer quality sleep, which further exacerbates fatigue. [2]
With an underactive thyroid (hypothyroidism), the thyroid gland does not produce enough of the hormones required to regulate metabolism. This leads to a slowdown in various bodily functions, including energy production and heart rate, which manifests in fatigue and weakness. People with hypothyroidism often experience persistent fatigue, even after adequate sleep. [2]
Chronic fatigue syndrome (CFS) is a complex disorder characterized by extreme, persistent fatigue that does not improve with rest and severely limits daily functioning. [2]
The exact causes of CFS are not fully understood, but immune system disorders, hormonal imbalances, and nervous system disorders are thought to play a role. Patients with CFS often also experience other symptoms, such as muscle pain, memory problems, and sleep disturbances, which further exacerbate fatigue.
Low moods and psychological illnesses exhibit neurochemical and hormonal imbalances in the brain that can affect motivation and energy, which can lead to constant fatigue. Neurotransmitters such as serotonin and dopamine, which are essential for mood and sleep regulation, can be imbalanced in depressed mood, resulting in a lack of energy and fatigue. [2]
In addition, a lack of drive that often accompanies depressive moods or mental health issues exacerbates the situation, as less physical activity leads to lower endorphin production.
Seasonal allergies such as hay fever can also lead to constant fatigue, as the body's immune response to allergens consumes a lot of energy and causes inflammatory processes that can lead to exhaustion. [9]
In addition, some allergy medications, especially older antihistamines, can lead to typical symptoms such as fatigue as a side effect. Respiratory problems caused by allergies, such as blocked nasal passages or asthma, can also disrupt sleep, leading to inadequate rest and persistent fatigue.
To effectively combat your fatigue in everyday life, you can consider the following measures: [10]
Incorporating these tips into your daily routine can increase your energy and improve your quality of life.
You should see a doctor if your fatigue persists despite getting enough sleep, eating healthily, and exercising regularly, or if it comes on suddenly and severely affects your daily life.
It is also important to seek medical advice if your fatigue is accompanied by other symptoms such as weight changes, pain, or mood swings.
Treatment for fatigue starts with diagnosing the cause of your fatigue. The blood tests at CARE will give you an insight into your current state of health and can identify anemia, nutritional deficiencies, and other potential causes of your fatigue.
Many of our CARE members have been able to identify iron deficiencies, vitamin deficiencies, or hormonal imbalances that they were previously unaware of.
If you would like more support on your health journey, you can find out more about sleep management, nutrition optimization and stress reduction measures to improve your quality of life and combat your constant fatigue with additional health coaching.
Elena is an enthusiastic Health Coach and blog writer at CARE, with a passion for holistic medicine and health. Previously, Elena worked for almost five years as a coach leading retreats, workshops, and seminars. These included mind-body therapy: breath work, meditation, and massage; as well as energy force therapy: reiki, and qi gong; and third expressive therapy: movement, writing and support groups. Elena shares exciting articles on the blog, on the topic of where the alternative and traditional medicine intersect with Western Medicine. Elena is also the driving force behind the CARE community. In her spare time, she enjoys hiking, traveling to remote locations and dancing. You might also see her on the lake of Zurich as a coast guard. Join her on her journey to learn more about health and discover the world of preventive medicine! Visit all articles written by Elena!
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